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PRIME(ary) Importance Of Nitric Oxide

Original Article by Dr. Donald Layman

April 2013 dianna

Nobel Prize in medicine was awarded for the discovery of nitric oxide in 1998

The past last quarter of a century has witnessed extraordinary advances in medicine and nutrition derived from discoveries about how cells exchange information, what we call cell signaling. Our earliest understanding about cell signaling came from hormones like insulin or neurotransmitters like serotonin, but as science techniques became progressively more effective, our understanding moved down to smaller and smaller molecules.

In 1998, the Nobel Prize in medicine was awarded for the discovery of a little molecule called nitric oxide that has a really big role as a regulator of the cardiovascular system.

The list of nitric oxide roles in signaling seems virtually endless and includes increasing glucose uptake into muscle, and increasing fat burning (lipolysis), preventing LDL oxidation and superoxide damage (primary causes of heart disease), reducing platelet aggregation (blood clots), and vasodilation (lowering blood pressure).


Relaxing the blood vessels is labeled vasodilation and allows blood vessels to relax

Between these contrasting roles, possibly the most valuable is regulating the smooth muscles that line the blood vessels. Nitric oxide (NO) is produced in the endothelium cells of the blood vessels, and then the Nitric Oxide is dispatched to the smooth muscles surrounding the blood vessels allowing them to relax.

Relaxing the blood vessels is labeled vasodilation and expands the small capillaries throughout the body to increase blood flow and increase the flow of oxygen and nutrients to muscles and organs.

When we’re young, all of these signaling systems are likely to work very well; although as we become older the signals become less effective. Our blood vessels and our muscles become less pliable. We arise each morning feeling stiff and aching. The same is true for our blood vessels. As we age our blood vessels become more stiff and less pliable. This change is generally called “hardening of the arteries” or arteriosclerosis and often results in increasing blood pressure. One of the causes of reduced flexibility of the arteries is declining Nitric Oxide production.


Nitric Oxide is an essential target for medical therapies since aging and lots of cardiovascular illness is caused by arteriosclersis "hardening of the arteries"

Nitric oxide is created in the body by two different ways. This is critical because once Nitric Oxide is produced it only lasts about 2 seconds, so the body needs a consistent supply. One way, Nitric Oxide is produced from the amino acid arginine.

Arginine is thought a non-essential (or dispensable) amino acid due to the fact that adequate amounts are produced daily in the kidneys. Arginine in the blood is made use of by the blood vessels to make Nitric Oxide making use of the enzyme nitric oxide synthase (NOS). NOS converts arginine into Nitric Oxide plus citrulline.

NO has actually become an essential target for medical therapies since aging and lots of cardiovascular illness relates to decreased vasodilation and high blood pressure.


While arginine degrees are high, the NOS system just cannot utilize it

One technique has actually been use of arginine supplements. In cases where people have advanced illness, physicians have actually discovered that very high dosages of arginine (12 to 25 grams everyday) can enhance NO manufacturing and enhanced vascular function.

Arginine supplements in less significantly ill people or small doses (less than 8 grams day-to-day) have actually had very little success. One reason is that the arginine levels in the blood are usually high-- practically 10-times the degree required for the NOS enzyme to produce Nitric Oxide.

Arginine levels are so high this is frequently described as the arginine paradox-- arginine supplements merely make no sense when blood levels of arginine are currently 10-times even more than can be made use of. Why does Nitric Oxide signaling decrease with age if arginine is so high? One answer is that the function of the NOS enzyme decreases with advancing age. While arginine degrees are high, the NOS system just cannot utilize it.

The Primary Importance of Nitric Oxide is Available in Qivana’s Prime


People who consumed more vegetables had decreased risk of heart disease, it might be do to nitrates and Nitric Oxide

Because Nitric Oxide is so critical, our bodies evolved an alternate way to make Nitric Oxide. This pathway uses naturally occurring nitrate salts found in many plants such as arugula, beets, broccoli, lettuce, rhubarb, and spinach.

We have known for years that people who consumed more vegetables had decreased risk of heart disease. It was taken for granted that the benefits connected to things like additional antioxidants, increased fiber, or lower saturated fat intake; but information suggests it may be due to nitrates and Nitric Oxide.

This other pathway for producing Nitric Oxide from nitrates begins in the mouth where bacteria convert the plant salts from nitrate to nitrite. We ingest the nitrite with our meals, and it is absorbed in the small intestines into the blood.


Qivana's PRIME Nitric Oxide Activator to the rescue

Blood transports the nitrite to every cell throughout the body where the nitrite is transformed to Nitric Oxide by numerous enzymes called reductases. This pathway takes over as the NOS system decreases with aging. The only downer is you must get your 8 to 10 servings of high nitrate plants every day … that’s a lot of spinach!

But there is good news – Qivana has a PRIME(ary) solution. Qivana’s PRIME system maximizes the nitrate pathway. PRIME Nitric Oxide Activator delivers the ideal nitrate and nitrite mixture complete with an oral probiotic to maximize the natural oral NO production system. This is break through science in optimizing your vascular function and health. Nitric Oxide status is important for everyone.

The PRIME system allows you to evaluate your blood level of nitrite with an easy saliva test. Blood nitrite has been shown to be the best biomarker for blood Nitric Oxide levels. If your blood levels of nitrites are optimal you'll know for sure within seconds. If not, use Qivana’s PRIME Nitric Oxide Activator to protect this critical cell signaling system.


Dr. Donald K. Layman is Professor Emeritus of Nutrition in the Department of Food Science and Human Nutrition at the University of Illinois. He has more than 33 years of training and research experience, Dr. Layman has various awards and awareness, consisting of awards from the American Society for Nutritional Sciences, the National Institutes of Health and the Nutrition and Metabolism Society.



Qivana April 2013 Article by Dr. Donald Layman

Keywords: Prime nitric oxide activator, Qivana, nitric oxide, nitric oxide (NO), Dr. Donald Layman, signaling Nobel Prize, cardiovascular system, vasodilation, lowering blood pressure, reducing platelet aggregation, blood clots, LDL oxidation, superoxide, heart disease, glucose uptake, fat burning, lipolysis, endothelium cells, blood vessels, hardening of the arteries, arteriosclerosis, declining NO production, amino acid, arginine, NOS, citrulline, spinach, beets, arugula, lettuce, rhubarb, broccoli, nitrite, nitrate, saliva test, nitric oxide instant indicator

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PRIME Nitric Oxide Activator contains L-citrulline, which converts to L-arginine in the body. Researchers have suggested and reported that L-arginine made from L-citrulline is much more effective at raising NO levels than taking L-arginine directly.
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