Qivana of Honolulu Products Line: Prime, Qore and Metaboliq

Qivana PRIME Nitric Oxide Activator

2012 Qivana

The Concept

The new PRIME Nitric Oxide Activator is a cutting-edge nutritional supplement, with nearly a decade of research investment. It is scientifically designed with a completely unique and improved method for restoring Nitric Oxide back to optimal levels in adult men and women.

Nitric Oxide is a gaseous molecule that plays a critical role in cell signaling, and has serious consequences on the health of the cardiovascular system and many other physiological processes. It’s documented that the human body produces less Nitric Oxide with age; a typical 40-year old adult creates approximately 50 percent less Nitric Oxide than a healthy 20-year-old.

Scientific evidence suggests that increasing Nitric Oxide production may improve cardiovascular health by facilitating highly specific circulatory system processes, including vasodilation. The PRIME Nitric Oxide Activator contains several Nitric Oxide precursors, oral probiotics and other phytochemicals designed to improve and optimize endogenous Nitric Oxide production.

PRIME also comes with a novel Instant Indicator that gives accurate measurements of total body Nitric Oxide availability based on a saliva sample. PRIME provides the tools needed to improve cardiovascular health and overall well being.

Nitric Oxide Production Declines With Age


Nitric Oxide Public Health Relevance

Approximately 17.3 million people died from cardiovascular disease in 2008, according to the World Health Organization (WHO). Cardiovascular disease accounted for 30 percent of all deaths worldwide. Rising levels of obesity, hypertension, type 2 diabetes, and other chronic illnesses are a growing public health concern.

These chronic diseases are significant risk factors for later cardiovascular disease. The WHO estimates that cardiovascular disease will become the leading cause of death by 2030, contributing to 23.6 million deaths worldwide.

In addition to reducing longevity, cardiovascular disease causes significant public health burdens. Individuals with cardiovascular disease experience increased functional disability, utilize primary care and hospital resources more frequently, use more prescription medications, and often require rehabilitation services. In 2008, the total cost of cardiovascular disease and stroke in the United States was $297.7 billion, according to a 2012 report from the American Heart Association.

Growing awareness of the serious medical and financial burden of cardiovascular health has generated interest in biological mechanisms and pharmaceutical interventions that can lower cardiovascular risk. Nitric Oxide (NO), sometimes known, as nitrogen monoxide has emerged as a compound of interest in improving overall cardiovascular functioning as well as benefiting other body systems.

Nitric Oxide is a cell-signaling molecule that is implicated in a host of physiological processes including blood circulation, memory, cognitive functioning, neurotransmission, gastrointestinal processes, gene regulation and delivery of nutrients to cells.

Because of the varied effects of NO, dysregulation of the Nitric Oxide signaling pathway is implicated in several health conditions including memory and cognition disorders, sexual dysfunction, autoimmune disorders and nearly all cardiovascular risk factors.

Although NO has a recognized role in a variety of physiological processes, it is perhaps best known as a molecule beneficial to cardiovascular health. In 1992, the American Association for the Advancement of Science proclaimed NO the “Molecule of the Year” for its role as a biological messenger with beneficial effects on the cardiovascular system.

NO has been demonstrated to improve circulation, facilitate efficient delivery of oxygen and nutrients to cells, dilate arteries and support healthy blood pressure already within a normal range*. The PRIME Nitric Oxide Activator facilitates natural NO production pathways in the body by providing the best raw materials by which the body can synthesize Nitric Oxide.

It does this by providing the body with several Nitric Oxide precursors and compounds proven to efficiently and effectively convert to NO in the body. This product increases the body’s natural production of this beneficial molecule.

Although scientists have found NO to be a potent activator of circulatory processes, the general population remains uninformed of the potential benefits of this molecule. In a 2003 survey conducted by NFO Plog Research Inc., researchers found that less than 1 percent of individuals correctly identified Nitric Oxide as a compound that benefits blood circulation.

Nearly one-fourth of respondents confused Nitric Oxide with laughing gas, or nitrous oxide. As scientific research about the benefits of Nitric Oxide continues to accumulate, it is important for scientists and health professionals to disseminate this crucial information to the public.


Things You Might Want to Know About Nitric Oxide

  • In 1998 a Nobel Prize in Medicine was awarded scientists for their discovery of Nitric Oxide as a cellular signaling molecule.
  • Well over 100,000 scientific articles have been published about the effects of Nitric Oxide on cardiovascular health and other physiological processes.
  • More than 200 government-approved Nitric Oxide clinical trials are currently underway.
  • African-American populations have been shown to naturally produce less Nitric Oxide than people of other ethnicities.
  • The average 40-year-old produces 50 percent less Nitric Oxide than he or she did at age 20.
  • Declining N-O production causes hardened arteries, restricted circulation and plaque accumulation.
  • Lower natural endothelial Nitric Oxide production is associated with future atherosclerotic disease progression. PrimeDisplay









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"The discovery of Nitric Oxide is one of the most important in the history of cardiovascular medicine" ~ President of the American Heart Association

"Nitric Oxide is the body's way of protecting against cardiovascular disease" ~ UCLA Department of Molecular and Medical Pharmacology

"Any risk factor for cardiovascular disease is associated with loss of Nitric Oxide." ~ Mayo Clinic Research

Get ready to revolutionize your health and wealth!

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• Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics – 2012 update: A report from the American Heart Association. Circulation. 2012 Jan; 125(1): e2-e220.

• Marsh N, Marsh A. A short history of nitroglycerin and Nitric Oxide in pharmacology and physiology. Clin Exp Pharmacol Physiol. 2000 Apr; 27(4): 313-9.

• Palmer RMJ, Ferrige AG, Moncada S. Nitric Oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987 June; 327(11): 524-526.

• Loscalzo J, Welch G. Nitric Oxide and its role in the cardiovascular system. Prog Cardiovasc Dis. 1995 Sept; 38(2): 87-104.

• Zand J, Lanza F, Garg HK, Bryan NS. All-natural nitrite and nitrate containing dietary supplement promotes Nitric Oxide production and reduces triglycerides in humans. Nutr Res. 2011; 31: 262-269.

• Bryan NS. Application of Nitric Oxide in drug discovery and development. Expert Opinions in Drug Discovery. 2011 Nov; 6(11): 1139-54.

• World Health Organization. Cardiovascular diseases fact sheet; 2011.

• Bondonno CP, Croft KD, Puddey IB, Considine MJ, Yang X, Ward NC, Hodgson JM. Nitrate causes a dose-dependent augmentation of Nitric Oxide status in healthy women. Food Funct. 2012 Feb.

• Serafim RA, Primi MC, Trossini GH, Ferreira EI. Nitric Oxide: State of the art in drug design. Curr Med Chem. 2012 Jan; 19(3): 386-405.

• Naseem KM. The role of Nitric Oxide in cardiovascular diseases. Mol Aspects Med. 2005 Feb; 26(1-2): 33-65.

• Iwata NG, Pham M, Rizzo N-O, Cheng AM, Maloney E, Kim F. Trans fatty acids induce vascular inflammation and reduce vascular Nitric Oxide production in endothelial cells. PLoS One. 2011; 6(12): e29600.

• Iachini Bellisarii F, Radico F, Muscente F, Horowitz J, De Caterina R. Nitrates and other Nitric Oxide donors in cardiology - Current positioning and perspectives. Cardiovasc Drugs Ther. 2011 Dec.

• Toda N. Age-related changes in endothelial function and blood flow regulation. Pharmacol Ther. 2012 Feb; 133(2): 159-76.

• Castiglione N, Rinaldo S, Giardina G, Stelitano V, Cutruzzolà F. Nitrite and nitrite reductases: From molecular mechanisms to significance in human health and disease. Antioxid Redox Signal. 2012 Feb.

• Bescós R, Sureda A, Tur JA, Pons A. The effect of Nitric-Oxide-related supplements on human performance. Sports Med. 2012 Feb; 42(2): 99-117.

• Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ, Ahluwalia A. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived N-O. Hypertension. 2010 Aug; 56(2): 274-81.

• Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008 Mar; 51(3): 784-90.

• Guo LY, Hung TM, Bae KH, Shin EM, Zhou HY, Hong YN, Kang SS, Kim HP, Kim YS. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 2008 Sep 4; 591(1-3): 293-9.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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PRIME Nitric Oxide Activator contains L-citrulline, which converts to L-arginine in the body. Researchers have suggested and reported that L-arginine made from L-citrulline is much more effective at raising NO levels than taking L-arginine directly.
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